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Genetic Thrombophilia Variants and Risk for Preeclampsia Among American Indians

OBJECTIVE: To determine the prevalence of thrombophilic genetic variants in an American Indian population and determine if they are associated with preeclampsia. METHODS: A total of 87 cases, 165 controls and an additional 75 population-based controls were genotyped for two thrombophilic polymorphisms. RESULTS: The allelic prevalence of the factor V Leiden and 20210 G/A prothrombin variants in this population was 2.1% and 0.5% respectively. No statistically significant associations between these genetic variants and preeclampsia were found. CONCLUSION: The prevalence of thrombophilic variants is of possible public health significance for other morbidity; but perhaps not in relation to preeclampsia.